Work carried out as part of our collaboration with Profs. Nigel Scrutton, David Leys and coworkers at the University of Manchester has just been accepted for publication in ACS Catalysis. The project involves cystallography, the development of metabolic engineering platforms and computational studies of the bacterial monoterpene synthases Linalool synthase and 1,8-cineole synthase. These compounds are industrially important as flavours and fragrances (see this blog post about Lavender) and can be produced in better yields, with higher purity by the bacterial enzymes compared to plant species.
See the article in ‘Just accepted’ form:
“Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1,8-cineole synthase” Karuppiah et al., ACS Catalysis, DOI:10.1021/acscatal:7b01924